TABLE 1

Effect of DDX3X depletion or overexpression on HSV-1 gene expression

GeneProteinValue under the indicated DDX3X condition (%)a
DepletionOverexpression
mRNA levelProtein levelmRNA levelProtein level
RL2ICP072 ± 1036 ± 2*47 ± 2912 ± 9
RS1ICP471 ± 718 ± 0.6†48 ± 148 ± 4*
UL29ICP865 ± 452 ± 643 ± 1528 ± 5
UL23TK69 ± 1044 ± 1458 ± 129 ± 2*
UL31pUL3171 ± 739 ± 1348 ± 1411 ± 0.04
UL48VP1658 ± 722 ± 1*41 ± 101 ± 1*
  • a Significant differences between mRNA and protein levels (means ± standard deviations) for each condition in two independent experiments based on bilateral Student's t tests are indicated. *, P < 0.05; †, P < 0.001.