TABLE 1

HLA class I-associated peptides derived from the HIVconsv immunogenb

SequenceLength (aa)Position(s) in HXB2 (aa)Positions in HIVconsv (aa)Presence of exact match in LANL-HSDNetMHC binding affinity (nM)HLA allelePEAKS score (−10logP)Sample collection time(s) (h)
YKRWIILGLNK11Gag 262–27258–68No11,608A*03:0115.301.5
KRWIILGLNK10Gag 263–27259–68Yes6,379A*03:0116.352.5
IYKRWIILGLNK12Gag 261–27257–68No1,472A*03:0115.323.5
IILGLNK7Gag 266–27262–68NoNAA*03:0114.822.5, 3.5
FPISPIETVPVKL13Pol 155–167194–206No163 (WB)B*07:0256.523.5, 6
SPIETVPVKL10Pol 158–167197–206Yes191 (WB)B*07:0241.332.5, 3.5, 6
AIFQSSMTK9Pol 313–321351–360Yes20 (SB)A*03:0147.952.5, 3.5, 6
RKGGIGGYSAG11Pol 902–912663–673Yes20,750B*07:0214.826
RTWKSLVK8Vif 19–26412–419No39 (SB)A*03:0128.896
KIWPS-RWKPKa10Gag/Pol131–140NA71 (WB)A*03:0119.256
KLTP-WVPAHKa10Env/Pol518–527NA19 (SB)A*03:0140.526
  • a Peptides spanning a junction (-) between two conserved regions in the HIVconsv immunogen, thus creating a novel epitope not present on HIV-1-infected cells.

  • b LANL-HSD, Los Alamos National Laboratory HIV Sequence Database; SB, strong binder; WB, weak binder; NA, not applicable; −10logP, negative decadic logarithm of P, the probability that the identification is a random event.