TABLE 1

Association of CD8+ T cell responses to 19 epitopes with pVL and CD4 count in chronically HIV-1-infected Japanese individuals

EpitopeSequenceLocationHLA restrictionFrequencyMedian pVL (copies/ml)Median CD4 (cells/μl)P valueaq valueb
RespondersNonrespondersRespondersNonrespondersRespondersNonresponderspVLCD4pVLCD4
NefTY11TQGYFPDWQNYNef117-127B*15:0133903,40025,0003863210.220.380.250.4
GagEM11EGATPQDLNTMGag177-187B*67:0173862,20025,0004403210.0110.0250.0240.044
C*08:01239129,00025,0004513220.860.360.860.4
GagTL9TPQDLNTMLGag180-188B*67:01153788,90025,0004403190.116.5 × 10−30.140.015
GagMI8MQMLKETIGag198-205B*52:01423515,35027,0004373133.3 × 10−44.9 × 10−41.6 × 10−32.3 × 10−3
GagQA11QMLKETINEEAGag199-209B*52:01113823,10026,5004323214.2 × 10−50.0442.7 × 10−40.07
GagRI8RMYSPTSIGag275-282B*52:016033310,65027,0004463092.1 × 10−33.2 × 10−76.6 × 10−36.1 × 10−6
GagYL9YVDRFYKTLGag296-304C*03:0423912,88525,0003033220.0790.790.120.79
GagWV8WMTETLLVGag316-323B*52:01433504,70028,0004463091.0 × 10−68.7 × 10−71.9 × 10−58.3 × 10−6
GagNL11NPDCKTILKALGag327-337B*67:0193842,20025,5004403212.4 × 10−30.026.6 × 10−30.038
GagGM9GPAATLEEMGag338-346B*67:01139278025,0006933220.140.110.160.15
GagAA9ATLEEMMTAGag341-349A*02:06303638,65027,0004373140.0196.6 × 10−40.0362.5 × 10−3
GagKL9KELYPLASLGag481-489B*40:021238120,00025,0004803210.680.0170.720.035
PolSV9SQIYAGIKVPol423-431A*02:064834515,00027,0003923130.044.6 × 10−30.0640.015
PolSI8SQYALGIIPol654-661B*52:01433505,00028,0004563101.3 × 10−52.5 × 10−61.3 × 10−41.6 × 10−5
PolLA9LEGKIILVAPol783-791B*40:06163774,15027,0004373215.6 × 10−40.0782.1 × 10−30.11
PolIT10IEAEVIPAETPol799-808B*40:062536813,00026,5003533214.5 × 10−30.190.0110.22
PolGI8GERIVDIIPol912-919B*40:023935414,00028,0004053170.0215.5 × 10−30.0360.015
PolTL8TDIQTKELPol921-928B*40:0253887,20025,0004783220.110.170.140.22
  • a The statistical analyses of differences in pVL or CD4 count between responders to each epitope and nonresponders were conducted by using the two-tailed Mann-Whitney test. Bold indicates that differences were statistically significant.

  • b Multiple tests were performed by using the q value, a measure of significance in terms of the false-discovery rate (46). A significance threshold for q of <0.2 was employed.