TABLE 2

Comparison of T cell reactivity after vaccination and natural infection

ParameterVaccine recipients (NIH)Naturally infected donors (Sri Lanka)c
MonovalentbTetravalentPrimarySecondary
Frequency of responders (%)59732243
Avg no. of epitopes per donor68611
Avg response per donora9523596220
n411155127
  • a Expressed as IFN-γ SFC/106 PBMC.

  • b Expressed as the mean response observed in vaccinees with any of the four monovalent vaccines.

  • c Previously reported by Weiskopf et al. (20). Secondary donors are defined as having neutralization titers against at least two of the four serotypes.