TABLE 1

HAΔSA mutation does not affect binding to influenza virus antibodies CR6261, CH65, and C05a

InteractionKD (M)kon (1/s · M)koff (1/s)
CR6261 to HA4.40 × 10−91.36 × 1045.99 × 10−5
CR6261 to HAΔSA4.76 × 10−91.36 × 1046.46 × 10−5
CH65 to HA5.87 × 10−71.26 × 1057.38 × 10−2
CH65 to HAΔSA4.71 × 10−71.33 × 1056.26 × 10−2
C05 to HA3.33 × 10−82.96 × 1049.88 × 10−4
C05 to HAΔSA5.55 × 10−91.50 × 1058.32 × 10−4
  • a kon, association rate constant; koff, dissociation rate constant.