TABLE 5

DNA and protein divergence in ORFs across EEHV5A, EEHV5B, EEHV2, and EEHV1Aa

Gene locusEEHV1A coordinatesbProtein sizebNucleotide level divergence (%)cAmino acid level divergence (%)cChimeric domain
5A-5B5A-25B-25A-15A-5B5A-25B-25A-1
U39(gB)(74091–76511)(837)101615274.27.66.321CD-I
U38(POL)(76583–79038)(818)1.31817241.4111121CD-1
U33(83648–84183)(176)0.82828370252543
U28(RRA)(98637–99760)(374)0.417172308.68.616
U27.5(RRB)99804–100709(301)0.91616240.76.36.315
U27(PPF)(100960–101609)(216)0.81919310.9141425
U48(gH)(105396–105911)(172)01818380161634
U48.5(TK)105835–1069083441418203013191927CD-II
U49106910–1076282336.01110242.16.94.724CD-II
U50(PAC2)(107428–108178)(261)0.21818320191934
U51(vGPCR1)(109225–110065)(292)4.62223322.7171725
U57(MCP)(116671–117809)(380)0.21919270.39.29.219
U60(TERex3)(123674–124180)(169)1.213132101.31.33.0
U62(124231–124434)(75)0.51616290101019
U71(MyrTeg)132954–133241988.724234414273056
U72(gM)133316–133613(101)0.31617210101012
U73(OBP)(134605–134430)(269)012122104.44.410
U76(POR)(139815–141295)(493)0.21313220.44.14.17.8
U77(HEL)(141294–141793)(181)0.41414240.76.06.014
U77.5(ORF-M)143988–1455114841.11617290101017CD-III
U80.5(ORF-N)145642–1459591062823273832243347CD-III
U81(UDG)146027–1469803242723283323212029CD-III
U82(gL)146946–1477763122717273426162644CD-III
U82.5(ORF-Oex3)147694–147958(88)2321253221202025CD-III
U82.5(ORF-O)147700–1489854873654d3453d
U83.5(ORF-P)146932–1506385263348d3352d
U85.5(ORF-K)152042–154436(678)1.32322410.4292748
U86.5(ORF-L)155053–155356(97)1.41012301.07.08.420
  • a The prototype genomes used were EEHV5A(NAP50), EEHV5B(NAP58), EEHV2(NAP12), and EEHV1A(NAP18). The rows in the table shown in bold type indicate ORFs with high-level variability (hypervariable genes) between EEHV5A and EEHV5B.

  • b The values in parentheses indicate that incomplete ORFs were used.

  • c The divergence between EEHV5A and EEHV5B (5A-5B), EEHV5A and EEHV2 (5A-2), EEHV5B and EEHV2 (5B-2), and EEHV5A and EEHV1 (5A-1) is shown.

  • d These values show divergence between EEHV5B and EEHV1A.