TABLE 1

Virus neutralization characteristics at IC50 and IC80

AntibodyNo. of virusesNo. (%) of viruses neutralized at:Titer of:
Neutralized virusesaAll virusesa
<50 μg/ml<1 μg/mlMedianGeometric meanFold improvement from VRC01MedianGeometric meanFold improvement from VRC01
Value(s) determined at IC50
VRC01179159 (89)138 (77)0.230.2210.2970.434
VRC07179166 (93)149 (83)0.1190.1141.90.1290.1872.3
VRC07-501-LS179171 (96)164 (92)0.050.0415.40.0520.0587.5
VRC07-508-LS179168 (94)159 (89)0.040.0435.10.0510.0696.3
VRC07-523-LS179171 (96)165 (92)0.0460.0395.60.0470.0557.9
VRC07-544-LS179170 (95)162 (91)0.0580.054.40.0650.0735.9
Value(s) determined at IC80
VRC01179156 (87)78 (44)1.0130.981.31.775
VRC07179164 (92)122 (68)0.410.4142.40.4620.6562.7
VRC07-501-LS179169 (94)154 (86)0.1930.166.10.2080.2297.7
VRC07-508-LS179165 (92)146 (82)0.1880.1785.50.2110.2916.1
VRC07-523-LS179170 (95)152 (85)0.2290.19750.2420.2696.6
VRC07-544-LS179169 (94)146 (82)0.2360.2094.70.2690.2926.1
  • a Median and geometric mean titers were calculated only for samples with an IC50 or IC80 of <50 μg/ml.

  • b Median and geometric mean titers were calculated for all viruses, and values of >50 μg/ml were set to 100 μg/ml.