TABLE 2

Baseline gene predictors used to distinguish patients with chronic HCV infection who are successfully treated from patients who relapse after ending IFN-based therapya

GeneGene symbolFunctional association(s)
Spindlin 1SPIN1Cell cycle; reproductive process in a multicellular organism
TAF13 RNA polymerase II, TBP-associated factor, 18 kDa227278_atBasal transcription factors
HAUS augmin-like complex, subunit 2HAUS2Mitotic cell cycle
E4F transcription factor 1E4F1DNA replication
DEAD (Asp-Glu-Ala-Asp) box polypeptide 49DDX49ATP-dependent helicase activity
AE binding protein 2AEBP2Chromatin organization, modification
Ring finger protein 26RNF26Protein-DNA and protein-protein interactions
SEC63 homolog (Saccharomyces cerevisiae)SEC63Protein folding, localization, and transport
235901_atProteolysis; cell-cell signaling
Phospholipase C, beta 2PLCB2Inositol phosphate metabolism, calcium signaling pathway, chemokine signaling pathway, T cell receptor
Glutaryl-CoA dehydrogenaseGCDHFatty acid, lysine degradation, tryptophan metabolism
Glucosidase, beta (bile acid) 2GBA2Lipid and glycolipid metabolism
Diacylglycerol O-acyltransferase 1DGAT1Glycerolipid and retinol metabolism
Leucyl/cystinyl aminopeptidaseLNPEPRenin-angiotensin system
Glycoprotein Ib (platelet), beta polypeptide206655_s_atECM-receptor interaction; hematopoietic cell lineage
Immunoglobulin heavy constant muIGHMB cell development, activation
Leukotriene B4 receptorLTB4RNeuroactive ligand-receptor interaction
KIAA1949KIAA1949
Nitrilase 1NIT1
Yippee-like 2 (Drosophila melanogaster)YPEL2
Family with sequence similarity 65, member AFAM65A
  • a TBP, TATA box binding protein; CoA, coenzyme A; ECM, extracellular matrix.