TABLE 1

Improved neutralization potency of 4E10 by modifying its lipid-interacting CDR H3 loop

VirusClade4E10 IgG4E10 WTa Fab4E10 mutant Fab
IC50 (μg/ml)IC80 (μg/ml)IC50 (μg/ml)IC80 (μg/ml)IC50 (μg/ml)IC80 (μg/ml)
Du156.12C0.2451.0100.6672.3240.3581.103
92UG037.8A1.1047.1132.3739.6581.3495.319
TRO.11B1.2047.1672.4179.5631.1275.546
ZM197M.PB7C1.0448.4274.96920.4583.48812.452
T266.60AG3.57321.57039.182>5023.701>50
928-28AG5.87132.09214.06046.44210.66938.748
Q842.d12A12.30049.6139.95530.3295.94216.391
C2101.c1AE15.529>5017.30849.8518.15826.802
PVO.4B18.952>5040.485>5019.063>50
RHPA4259.7B12.811>50>50>50>50>50
  • a WT, wild-type.