TABLE 2

Antiviral activity induced by Ad5-poIRF7/3(5D)a

TreatmentMean ± SEM log no. of TCID50/ml
B18R and anti-IFN-α negativeB18R and anti-IFN-α positive
Ad5-poIRF7/3(5D)<0.1 ± 0.04.1 ± 0.4
Medium5.5 ± 0.06.3 ± 0.0
Ad5-Blue5.1 ± 0.45.4 ± 0.4
  • a FMDV titers (log TCID50/ml) recovered from the supernatants of IBRS-2 cells 24 h after infection with Ad5-poIRF7/3(5D) in the presence or absence of IFN-neutralizing agents (B18R and anti-porcine IFN-α antibody).