TABLE 1

Survival time of RIII mice and human-PrP-transgenic (tg650) mice inoculated with serial 10-fold dilutions of human vCJD brain, healthy brain, and BSE brain tissue

InoculumDilutionMean no. of days of survival time ± SEM (n/n0)a
tg650RIII
vCJD10−3NDb568 ± 31 (6/6)
10−4ND438c; 482 (2/7)
10−5802 ± 35 (6/6)609–975 (0/7)
10−6834 ± 51 (5/9)543–975 (0/7)
10−7651c (1/9)538–975 (0/7)
10−8687–1062 (0/8)ND
Healthy brain10−1623–1098 (0/9)422–945 (0/7)
BSE (Fr3)10−1753 ± 60 (3/5)413 ± 8 (9/9)
  • a n/n0, number of diseased or PrPres-positive mice/number of inoculated mice. For mice with negative results, only the range of survival time is given. Data in italics are from references 28 and 52.

  • b ND, not done.

  • c Mouse with detectable levels of PrPres in spleen but not brain.