TABLE 4

HLA A*02 modifies immune correlates of risk of HIV-1 infectiona

Immune variableHLA typeEst. OR95% CIP value (H0: OR = 1)A*02+/− interaction P valueA*02+/− interaction q value
LowerUpper
IgA C1 biotin* (positive vs negative response)Overall3.151.486.710.003
A*02+1.260.315.150.750.130.44
A*026.012.1916.50.0005
Peptide microarray 163-TSIRDKVQKEYALFY (quantitative analysis**)A*02+0.840.421.700.630.0600.41
A*021.921.073.450.030
Peptide microarray 163-TSIRDKVQKEYALFY (med vs low response***)A*02+1.710.407.370.47
A*021.630.485.560.44
Peptide microarray 163-TSIRDKVQKEYALFY (high vs low response***)A*02+0.660.152.960.59
A*026.041.8020.30.0036
  • a *, OR is for vaccine recipients with a positive versus a negative response using positivity criteria determined previously (15); **, OR is per standard deviation change in the assay measurement; ***, OR is for vaccine recipients with a high (or medium) response versus a low response; —, not applicable.