Table 1

CTL escape mutations in HIV-1B Gag

Escape mutationaGag proteinAssociated HLA class I allelebCTL epitopecEpitope sequenced
K26Rp17B*08 (nonprotective)B*08-GK9GGKKKYKLK
K28Rp17A*03 (nonprotective)A*03-RK9RLRPGGKKK
K28Qp17A*03 (nonprotective)A*03-RK9RLRPGGKKK
Y79Fp17A*01(nonprotective)A*01-GY9GSEELRSLY
Y79Hp17Cw14 (protective)Cw14-LL8LYNTVATL
A81T*p17B*08 (nonprotective)B*08-EV8ELRSLYNTV
A83Vp17A*11 (nonprotective)A*11-TI9[A]TLYCVHQR
R91Gp17A*11 (nonprotective)A*11-TK8TLYCVHQR
A146Pp24B*57 (protective)B*57-ISW9[A]ISPRTLNAW
I147Lp24A*25 (protective)A*25-QW11QAISPRTLNAW
A163Gp24B*57 (protective)B*57-KF11KAFSPEVIPMF
Q182Tp24B*42 (undetermined)B*42-TL9TPQDLNTML
T186Mp24Cw08 (protective)Cw08-TL9TPQDLNTML
E211Dp24A*25 (protective)A*25-EW10ETINEEAAEW
T242Np24B*57 (protective)B*57-TW10TSTLQEQIGW
G248Ap24B*57 (protective)B*57-TW10TSTLQEQIGW
D260E*p24B*35 (nonprotective)B*35-NY10NPPIPVGEIY
R264Kp24B*27 (protective)B*27-KK10KRWIILGLNK
L268Mp24B*27 (protective)B*27-KK10KRWIILGLNK
T280Sp24B*52 (protective)B*52-RI8RMYSPTSI
K302Rp24B*14 (protective)B*14-DA9DRFYKTLRA
T303Vp24B*14 (protective)B*14-DA9DRFYKTLRA
D312E*p24B*44 (nonprotective)B*44-AW11AEQASQEVKNW
K331Rp24B*08 (nonprotective)B*08-DL9DCKTILKAL
G357Sp24A*11 (nonprotective)A*11-AK11ACQGVGGPGHK
T427Np7B*40 (protective)B*40-TL8TERQANFL
K436Rp1B*13 (protective)B*13-RI9RQANFLGKI
I437Lp1B*13 (protective)B*13-RI9RQANFLGKI
E482Dp6B*40 (protective)B*40-KL9KELYPLTSL
  • a CTL escape mutation denoted as susceptible residue followed by position (HXB2 Gag numbering) followed by escape residue; an asterisk denotes a putative negatope escape mutation.

  • b HLA class I allele associated with mutation expression in HIV-1B (56) and its protective value in HIV-1 infection (10).

  • c Defined CTL epitope spanning or immediately adjacent to the listed escape mutation.

  • d HIV-1B consensus sequence for each epitope; position of escape mutation underlined; brackets denote mutation adjacent to epitope.