Table 2

Fold changes in the mRNA levels of inflammatory molecules in the brains of WNV-infected WT and ASC−/− mice

GenemRNA fold changea
WTASC−/−
Casp15.01 ± 0.352.64 ± 0.45
Ccl2 (MCP-1)85.92 ± 10.20588.13 ± 31.61
Ccl3 (MIP-α)6.17 ± 0.6755.72 ± 2.52
Ccl4 (MIP-β)23.02 ± 1.2184.45 ± 4.82
Ccl5 (RANTES)52.89 ± 4.2390.51 ± 10.50
Ccr17.09 ± 0.429.85 ± 1.16
Ccr41.17 ± 0.043.48 ± 0.30
Ccr71.77 ± 0.166.06 ± 0.76
Cxcl10 (IP-10)641.36 ± 13.34831.75 ± 37.13
Cxcl11 (IP-9)9.35 ± 0.8545.25 ± 0.4
IFN-γ11.51 ± 1.5118.38 ± 1.98
IL-1018.70 ± 2.6410.56 ± 1.05
IL-43.80 ± 0.411.87 ± 0.05
TNF-α13.22 ± 1.122.63 ± 2.13
  • a The data are expressed as means ± standard deviations for a total of four animals from two independent arrays for each group.