Table 1

Coevolution of substitution patterns in HA and NA

ClusteraSubstitution(s) in HANo. of sequences in each clusterNo. (%) of sequences with the indicated mutation in NA
N44SV241IN396K
3.8S454N141 (7)4 (29)3 (21)
4.15S454N, E377K70 (0)1 (14)2 (29)
4.7S454N, E377K, S188T392 (5)36 (92)37 (95)
4.2S454N, E377K, S188T, D100N770 (0)74 (96)75 (97)
3.2S454N, E377K, S188T, A200T5549 (92)50 (94)51 (96)
4.9S454N, E377K, S188T, A200T, I463T1919 (100)19 (100)19 (100)
4.1S454N, E377K, S188T, A200T, S146G8682 (95)84 (98)84 (98)
4.5S454N, E377K, S188T, A200T, S146G, L-7M3333 (100)32 (97)33
4.1S454N, E377K, S188T, A200T, S146G, N263D1212 (100)12 (100)12 (100)
  • a The cluster number corresponds to the clusters shown in Fig. 3 and 4.