Table 1

Clinical symptoms of inoculated and contact ferrets

TreatmentChallenge virusMean max wt lossa (%)Mean max temp increaseb (°C)No. of seroconverted contact ferrets/total no. of contact ferretsc
InoculatedContactsInoculatedContacts
None6/6
Perth/094.32.01.00.93/3 (640)
IN/115.82.82.21.63/3 (1,015)
TIV10/18
Perth/096.33.01.31.04/9 (1,076)
IN/117.36.01.11.56/9 (640)
Monovalent vaccine5/9
    Perth/09 vaccineIN/118.16.31.31.12/3 (453)
    Beijing/92 vaccineIN/117.56.01.31.23/3 (640)
    IN/11 vaccineIN/111.60.80/3 (<10)
Perth/09 infection1/12
Perth/092.10.70/6 (<10)
IN/113.83.51.11.71/6 (1,280)
  • a Percentage of mean maximum (max) weight loss shown for each ferret group.

  • b Mean maximum temperature increase calculated as rise over ferret baseline of 38.3 ± 0.5°C. All maximum temperatures were observed on days 1 to 2 postinoculation.

  • c Seroconversion was measured by HI from sera collected on day 21 p.c. Geometric mean titers for seroconverted contact ferrets are shown in parentheses. Values of <10 were below the limit of detection in this assay.