Table 1

Previously published lambda-host PPIsa

Function/role and PPIλHostbDescriptionSource or reference
    1CIRecARecA degrades CIc26
    3CIRpoD28, 29
    4CIIClpYQClpYQ degrades CII in vitro26
    5CIIClpAPClpAP degrades CII in vitro26
    6CIIHflDHflD makes CII more vulnerable to FtsH (hfl = high-frequency lysogenization)30
    7CIIHflB*HflB (= FtsH) protease degrades CII31, 32
    8CIIRpoA33, 34
    10CIIIHflBCIII inhibits HflB; HflB degrades CIII26, 35
    11gpNNusATranscriptional regulation36
    12gpNLonLon degrades gpN26, 37
    13gpQσ70gpQ makes RNAP insensitive to cis termin29, 34, 38, 39
    14gpBGroEGenetic interaction; E. coli GroE4042
    15gpEGroEGenetic interaction41
    16gpJLamBLamB is the E. coli receptor4347
    17StfOmpCOmpC is a secondary E. coli receptor48
    18XisLonXis is degraded by E. coli Lon protease49
    19XisFtsHXis is degraded by E. coli FtsH protease49
    20XisFisBoth required for excision5052
    21IntIHFBoth catalyze recombination at attP/attB53, 54
    22GamSbcCSbcCD is a dsDNA exonuclease + ssDNA endonuclease55
    23GamRecBGam inhibits RecBCD56
    24NinBSSBNinB also binds ssDNA57
    25RalHsdRal inhibits restriction enzyme complex HsdMSR (by binding to HsdM or S)58
    26gpOClpXPClpXP degrades gpO26
  • a Modified from the study by Häuser et al. (15). CbpA (63) may interact with DnaA and SeqA (6466).

  • b Boldfacing indicates hosts required for infection (12). Underlining indicates host proteins found in our screen. *, HflB = FtsH.

  • c After DNA damage, RecA bound to single-stranded DNA (ssDNA) stimulates autocleavage of the CI repressor (26). dsDNA, double-stranded DNA.