Table 5

Inhibition of NA activity of MAb escape mutants by selecting MAbs

MAb groupMAbIC50 (ng/ml) of MAb escape mutant bearing the indicated mutationa
wt BR/07bK249EA250SA343EN273DV338MT339AT339IT339NT339PD341NI396TT397AT397NW456GN309S
A3A210.4>
4G27.7>>
B1H525.9>>>
2G668.1>>
2D931.2>>
3H1023.6>>>>
4E927.01,269
C1C785.7>
3C233.2>>
D2B528.2>
3H463.4>
E1H814.7200
2D4196>>
F4C41184
  • a IC50, median inhibition concentration measured with enzyme-linked lectin assay. Each mutant virus was tested only with the MAb used for its selection. >, no inhibition at 2 μg/ml, the highest MAb concentration tested; ≫, no inhibition at 16 μg/ml, the highest MAb concentration tested.

  • b IC50 of wt BR/07 virus was included for comparison.