Table 4

Amino acid changes in NA of mutant BR/07 viruses selected with N1 MAbs

MAb groupMAb for selectionMutantaAmino acid changeb
A3A23A2v1A250S
4G24G2v1K249E
4G2v2A343E
B1H51H5v1T339A
1H5v2T339I
1H5v3T339N
2D92D9v1T339I
2D9v2T339P
2G62G6v1T339A
2G6v2T339I
3H103H10v1N273D
3H10v2V338 M
3H10v3T339N
3H10v4T339P
4E94E9v1V338 M
C1C71C7v1D341N
3C23C2v1T339A
3C2v2T339I
D2B52B5v1T339N
3H43H4v1T397N
E1H81H8v1T397A
2D42D4v1I396T
2D4v2W456G
F4C44C4v1N309S
  • a MAb escape mutants of wt BR/07 were selected in eggs, followed by plaque purification.

  • b Only a single mutation was detected in the NA of each escape variant.