Table 3

Survival of guinea pigs tested for viremia levels

Treatment (amt in mg)Time of treatment (d.p.i.)Mean time to death ± SD (no. of animals that died)No. of survivors/total no. in groupcP valuedAvg wt loss (%)e
DEF201aMAbsb
PBS7.75 ± 0.96 (4)0/4NAf13
Normal mouse IgG control37.00 ± 0.00 (4)0/41.27E−0118
DEF201 only111.00 ± 1.00 (3)1/46.20E−0316
MAbs only (10)38 (1)3/43.46E−02<5
DEF201+MAbs (10)33NA4/46.20E−03<5
DEF201+MAbs (10)449.00 ± 1.15 (4)0/41.04E−0122
  • a Guinea pigs were treated intramuscularly with DEF201 or AdHu5-lacZ (2 × 108 PFU) at the indicated number of days postinfection (d.p.i.) with 1,000× LD50 of GA-ZEBOV.

  • b Guinea pigs were treated intraperitoneally with 5 or 10 mg total MAbs at the indicated d.p.i.

  • c Survival rates on day 28 after challenge.

  • d The log-rank (Mantel-Cox) test was used to calculate the P values. All treatment groups were compared to the corresponding PBS control group.

  • e Average of the maximum weight loss from the original weights on the challenge date.

  • f NA, not applicable.