Table 1

Equilibrium dissociation constants of hMAbs 4.8A, D11C, and 1.6D bound to DENV-1, -2, -3, and -4 sE

DENV sE boundEquilibrium KD (M) (mean ± SD) of hMAb:
4.8AD11C1.6D
DENV-1 sE1.2 × 10−9 ± 1.6 × 10−91.4 × 10−10 ± 1.2 × 10−101.5 × 10−10 ± 5.0 × 10−11
DENV-2 sE1.3 × 10−9 ± 1.1 × 10−91.2 × 10−10 ± 9.4 × 10−113.5 × 10−10 ± 4.5 × 10−10
DENV-3 sE7.4 × 10−10 ± 7.7 × 10−106.2 × 10−10 ± 3.2 × 10−101.8 × 10−10 ± 8.0 × 10−11
DENV-4 sE7.6 × 10−10 ± 5.4 × 10−102.9 × 10−10 ± 1.5 × 10−102.4 × 10−10 ± 5.6 × 10−11