Table 1

Characteristics of the V-heavy and V-light chains of the monoclonal antibodies CH01 to CH04 and VRC-CH30 to VRC-CH34 isolated from memory B cells of donor CH0219

MAbV-heavy chainV-light chainReference
VDJMutation frequency (%)HCDR3 length (aa)IsotypeGenBank accession no.VJMutation frequency (%)LCDR3 length (aa)aκ/λGenBank accession no.
CH013-203-1021324IgG1JQ2675233-201109κJQ2675192
CH023-203-1021424IgG1JQ2675243-201149κJQ2675202
CH033-203-1021224IgG1JQ2675253-201119κJQ2675212
CH043-203-1021224IgG1JQ2675263-20199κJQ2675222
VRC-CH301-23-1642313IgG1JN1594341-332165κJN15943725
VRC-CH311-23-1642413IgG1JN1594351-332155κJN15943825
VRC-CH321-23-1642313IgG1JN1594361-332175κJN15943925
VRC-CH331-23-1642313IgG1JN1594721-332175κJN15947025
VRC-CH341-23-1642213IgG1JN1594731-332175κJN15947125
  • a LCDR3, light-chain complementarity-determining region 3.