Table 3

Coding potential and putative transcription regulatory sequences of CoV genomesa

CoVORFLocation (nt)Length (nt)Length (aa)FramePutative TRS
TRS location (nt)TRS sequence(s) (distance in bases to AUG)b
PorCoV HKU151ab540–1934218,8036,268+3, +275ACACCA(459)AUG
S19324–228063,4831,161+119178ACACCA(145)AUG
E22800–2305125284+322777ACACCG(17)AUG
M23044–23697654218+123018ACACCA(20)AUG
NS623697–2398128595+323645ACACCA(46)AUG
N24002–250301,029343+223989ACACCA(7)AUG
NS724096–24698603201+324008GCACCA(82)AUG
WECoV HKU161ab511–1939718,8876,296+1, +366ACACCA(439)AUG
S19379–229183,5401,180+219233ACACCA(140)AUG
E22912–2316024983+122886ACACCA(20)AUG
M23153–23809657219+223130ACACCA(17)AUG
NS623809–2409028294+123768ACAUCA(35)AUG
N24115–251581,044348+124101ACACCA(8)AUG
NS7a24143–24811669223+224101ACACCA(36)AUG
NS7b25139–2527013244+225039AAACCA(94)AUG
SpCoV HKU171ab520–1935218,8336,278+1, +357ACACCA(452)AUG
S19334–229543,6211,207+219188ACACCA(140)AUG
E22948–2319624983+122925ACACCG(17)AUG
M23189–23842654218+223166ACACCA(17)AUG
NS623842–2412928896+123790ACACCA(46)AUG
N24150–251781,029343+324137ACACCA(7)AUG
NS7a25189–25623435145+125179ACACCA(4)AUG
NS7b25539–2575121371+325523ACUCCA(10)AUG
MRCoV HKU181ab596–1935618,7616,254+2, +164ACACCA(526)AUG
S19338–229913,6541,218+319192ACACCA(140)AUG
E22985–2323324983+222945ACACCG(34)AUG
M23226–23882657219+323203ACACCA(17)AUG
NS623882–2417229197+223857ACGCCA(19)AUG
N24355–253951,041347+124340ACACCA(9)AUG
NS7a25407–2558017458+325396ACACCA(5)AUG
NS7b25561–25932372124+1
NS7c25941–2619525585+325910ACACCA(25)AUG
NHCoV HKU191ab482–1932318,8426,281+2, +167ACACCG(409)AUG
S19305–230693,7651,255+319156ACACCG(143)AUG
E23069–2331724983+223013ACACCA(50)AUG
M23310–23960651217+323211ACACCG(93)AUG
NS623960–2423827993+223951ACACCU(3)AUG
N24248–252761,029343+224231ACACCU(8)AUG
NS7a25277–2557329799+225248ACACCG(23)AUG
NS7b25583–2587629498+225560ACACCA(17)AUG
WiCoV HKU201ab219–1883818,6206,207+3, +260ACACCA(153)AUG
S18817–224553,6391,213+118731ACACCU(80)AUG
E22455–2271526187+322380ACACCA(69)AUG
M22708–23358651217+122597ACACCG(105)AUG
NS623358–2363027391+3
N23646–246981,053351+323631ACACCA(9)AUG
NS7a24695–2492823478+224609AAACCA(80)AUG
NS7b25218–2546624983+325177ACACCG(35)AUG
NS7c25450–2571626789+125444ACACCGAUG
NS7d25752–2595220167+325735AAACCU(11)AUG
CMCoV HKU211ab478–1910318,6266,209+1, +363ACACCA(409)AUG
S19085–227293,6451,215+218939ACACCA(140)AUG
E22723–2297124983+122697ACACCA(20)AUG
M22973–23779807269+222938ACACCA(29)AUG
NS623779–2402424682+123727ACACCA(46)AUG
N24052–251071,056352+124039ACACCG(7)AUG
NS7a25107–2537927391+325036ACACCU(65)AUG
NS7b25391–2557618662+225379ACACCU(6)AUG
NS7c25500–25916417139+2
  • a PorCoV HKU15, WECoV HKU16, SpCoV HKU17, MRCoV HKU18, NHCoV HKU19, WiCoV HKU20, and CMCoV HKU21. aa, amino acid; nt, nucleotide.

  • b Boldface indicates putative TRS sequences. The nucleotide variations are in italic.