TABLE 3

Summary of NA activities of NA D151G mutants in the viruses tested

VirusaNA activity against 4-MU-NANA
kcat (s−1)Km (μM)kcat/Km (M−1 s−1)
HK680.492 ± 0.0441.81 ± 0.112.72 × 105
Cali090.308 ± 0.00113.3 ± 0.42.32 × 104
NY060.447 ± 0.0106.73 ± 0.316.64 × 104
sw/England920.698 ± 0.00548.6 ± 2.11.44 × 104
  • a The influenza viruses tested were A/Hong Kong/68 (H3N2) (HK68), A/California/04/2009 (H1N1) (Cali09), A/New York/06/2009 (H1N1) (NY06), and A/Swine/England/WVL7/1992 (H1N1) (sw/England92).