TABLE 2

Kinetic parameters for TZ205 D151 NA and TZ205 G151 NA against 4-MU-NANA at 37°C and inhibition by oseltamivir carboxylate and zanamivir

ParameterValue for parameter for:
TZ205 D151 NATZ205 G151 NA
kcat (s−1)26.8 ± 0.50.167 ± 0.002
Km (μM)29.0 ± 1.90.824 ± 0.058
kcat/Km (M−1 s−1)9.24 × 1052.03 × 105
Ki (nM)
    Oseltamivir carboxylate14.3 ± 2.317.0 ± 1.5
    Zanamivir0.16 ± 0.020.34 ± 0.07