Table 1

Association of D279, N362, and N283 polymorphisms in Env with the relative efficiency of entry using macaque versus human CD4 receptors

Presence of polymorphismanbInfectionc
ptCD4rhCD4
Median (range)PMedian (range)P
D2790.71880.3749
    +120.03 (0.01–0.11)0.02 (0.01–0.24)
    –310.01 (0.01–0.69)0.01 (0.01–0.71)
N2830.23910.0439
    +100.03 (0.01–0.59)0.12 (0.01–0.57)
    –330.01 (0.01–0.69)0.02 (0.01–0.71)
N3620.31620.7902
    +170.01 (0.01–0.35)0.05 (0.01–0.41)
    –260.01 (0.01–0.69)0.02 (0.01–0.71)
  • a Indicates the presence (+) or absence (–) of the indicated polymorphism.

  • b n, Number of Envs with or without the indicated polymorphism.

  • c Infection of cells expressing macaque CD4 relative to cells expressing huCD4. P values were calculated using a Mann-Whitney U test comparing the medians.