Table 2

Summary of the breadth and potency of MAb neutralization against 178 HIV-1 Env pseudoviruses

Virus cladeTiter (μg/ml)Measured by IC50Measured by IC80
VRC03aVRC06VRC06bVRC03aVRC06VRC06b
All clades<5049%22%44%41%16%37%
(n = 178)<135%10%28%24%3%20%
GMTb0.3611.80.4430.7633.81.1
A<5056%37%56%41%30%41%
(n = 27)<137%15%26%19%4%19%
GMT0.5101.70.8990.7756.21.7
B<5079%39%74%71%26%66%
(n = 38)<166%18%55%53%11%34%
GMT0.1731.50.2900.5042.00.831
C<5048%19%44%35%11%31%
(n = 54)<130%6%24%19%0%17%
GMT0.6523.20.7780.9927.31.2
D<5022%11%11%11%0%11%
(n = 9)<111%0%11%11%0%11%
GMT1.936.90.0550.286>500.2
CRF01_AE<5025%6%13%25%6%13%
(n = 16)<113%6%6%6%0%6%
GMT0.7740.2320.2914.61.02.6
CRF02_AG<5019%13%25%19%13%25%
(n = 16)<119%13%19%13%0%19%
GMT0.1000.6330.1000.9553.60.474
Other<5039%6%28%33%6%28%
(n = 18)<133%6%22%17%0%17%
GMT0.3130.3050.2240.7702.41.4
  • a Data for VRC03 were published previously (47). However, the data used in this paper are from a completely independent experimental run and are consistent with those generated from the previous study.

  • b Geometric mean titers (GMT) were calculated for neutralization-sensitive viruses with an IC50 or IC80 value of <50 μg/ml.