HLA-B*5702, HLA-B*5703, and HLA-B*5801 sequence differences
| Allele | Residue at positiona: | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alpha 1 domain | P2b | Alpha 2 domain | PCb | |||||||||||||||
| 9 | 24 | 45 | 46 | 63 | 66 | 67 | 77 | 94 | 95 | 97 | 99 | 103 | 114 | 116 | 156 | |||
| HLA-B*5702 | Y | A | M | A | E | N | M | N | T/S/A | I | I | V | Y | V | N | Y | R | W/F |
| HLA-B*5703 | − | − | − | − | − | − | − | − | T/S/A | − | − | − | − | − | − | − | L | W/F |
| HLA-B*5801 | − | − | T | E | − | − | − | − | T/S/A | − | − | R | − | L | D | S | − | W/F |
↵a − indicates conservation of the residue shown according to the HLA-B*5702 consensus. Positions 194, 282, 305 and 325, are located outside alpha 1/2 and differ as follows: HLA- B*5702/B*5703, I, V, A, and C; HLA-B*5801, V, I, T, and S, respectively.
↵b Residues bound at the B and F pockets, P2 and PC, respectively, are based on those previously published (5, 15).