Table 1

HLA-B*5702, HLA-B*5703, and HLA-B*5801 sequence differences

AlleleResidue at positiona:
Alpha 1 domainP2bAlpha 2 domainPCb
92445466366677794959799103114116156
HLA-B*5702YAMAENMNT/S/AIIVYVNYRW/F
HLA-B*5703T/S/ALW/F
HLA-B*5801TET/S/ARLDSW/F
  • a − indicates conservation of the residue shown according to the HLA-B*5702 consensus. Positions 194, 282, 305 and 325, are located outside alpha 1/2 and differ as follows: HLA- B*5702/B*5703, I, V, A, and C; HLA-B*5801, V, I, T, and S, respectively.

  • b Residues bound at the B and F pockets, P2 and PC, respectively, are based on those previously published (5, 15).