Table 3.

Neoglycoconjugates used for the study

Carbohydrate moietyEpitopeCarrierAvg no. of sugar residues per carriera
Lacto-N-fucopentaose IH type 1HSA25
BSA20
2′-FucosyllactosamineH type 2HSA19
A heptasaccharideA heptasaccharideHSA18
A trisaccharideA trisaccharideHSA19
BSA19
B trisaccharideB trisaccharideHSA19
BSA21
Lacto-N-difucohexaose ILewis bHSA8.5
Lacto-N-fucopentaose IIILewis xHSA12
Lewis y-tetrasaccharideLewis yHSA15
Lacto-N-fucopentaose IILewis aHSA23
Sialyl-Lewis x-hexaoseSi-Lewis xHSA13
Sialyl(mono), monofucosyllacto-N-tetraoseSi-Lewis aHSA12
Sialyl-lacto-N-fucopentaoseSi-LNFbHSA19
Sialyl-lacto-N-tetraoseSi-LNTbHSAN/A
Lacto-N-tetraoseLNTbHSAN/A
Sialyl-lacto-N-neotetraoseSi-LNnTcHSAN/A
  • a HSA and BSA linkers were acetyl phenylenediamine and six-atom spacer, respectively. N/A: not applicable.

  • b Possesses type 1 precursor motif.

  • c Possesses type 2 precursor motif.