Table 2.

Differences between the Smith strain sequencea and pSM3fr sequence

Group and genePositionMutationChange(s) in proteinReference(s)
Group A (sequence failures of the deposited Smith sequence identified before)
    M2020957ΔGFrameshift, ORF extended25,41
    M29/m29.136198+GM29 frameshift, ORF truncated; m29.1 frameshift, ORF extended3,41
    M3037260+CFrameshift, ORF extended3,41
    M3138803+GFrameshift, ORF extended25,41
    m143201403+GFrameshift, ORF extended9,41
Group B (sequence deviations of pSM3fr that are due to sequence failures of the deposited Smith sequence)
    M4561918+CFrameshift, fusion of M45 and m45.15,41
    M4974719T→CSer271 → Gly271
    M5892088ΔAProtein sequence deviation from amino acid 110 to amino acid 22041
92178C→GCGProtein sequence deviation from amino acid 110 to amino acid 220
92206CG→GCProtein sequence deviation from amino acid 110 to amino acid 220
92226G→AProtein sequence deviation from amino acid 110 to amino acid 220
92230G→AProtein sequence deviation from amino acid 110 to amino acid 220
92358ΔGProtein sequence deviation from amino acid 110 to amino acid 220
    M86123941A→CLeu1107 → Arg110741
123951T→GAsn1104 → His1104
    m107/m108162374T→Cm107 Leu131→ Pro131 m108 Ser133→ Gly13316,41
162380T→Cm107 Leu133 →Ser133 m108 Asn131→ Asp131
    m117.1/m117170652A→Cm117.1 Asp371 →Ala371 m117 Ser87 → Ala87
Group C (sequence deviations of pSM3fr)
    M1212052G→AGlu123 → Lys123
    M102146853G→AAsp420 → Asn42041
    M122 Ex5179136G→ASer227 → Phe22741
    m129187786ΔTFrameshift, ORF truncated41
  • a The Smith strain sequence was deposited in GenBank under accession number NC_004065 (36).