Table 2.

Relative mRNA expression levels of chemokines (ligands and receptors) that affect multiple cell typesa

Ligand or receptorOther nameRelative mRNA expression in groupb:
TMEV infected/PBS (day 2 p.i.)Day 6 p.i.
Seizures/PBSNo seizures/PBSSeizures/no seizures
PMN and monocyte/macrophage recruitment
    CCL1I-3091.62.21.02.1
    CCR81.64.21.52.7
    CXCL4PF-4−1.5−2.6−1.6−1.6
PMN recruitment and affects NK cells
    CCL20MIP-3α1.61.0−2.62.7
Monocyte/macrophage recruitment and affects NK cells
    CCL6MRP-11.52.41.61.5
    CXCL10IP-10637.11,266.0837.51.5
    CCL19MIP-3β2.13.55.2−1.5
    CXCL12SDF-1−1.1−2.1−1.1−1.9
    CX3CL1C3Xkine−1.1−1.71.6−2.8
    CCR71.611.33.43.4
PMN and monocyte/macrophage recruitment and affects NK cells
    CCL2MCP-1208.3453.872.56.3
    CCL4MIP-1β10.8105.985.01.2
    CCL3MIP-1α6.816.412.91.3
    CCL5RANTES19.2122.5122.8−1.0
    CCL7MCP-343.8186.999.01.9
    CCL8MCP-25.931.019.01.6
    CCL22MDC1.21.72.2−1.3
    CCR12.519.14.93.9
    CCR26.126.32.411.2
    CCR52.412.81.67.8
    CCR41.61.9−2.24.1
    CXCR3−1.438.579.9−2.1
  • a CCL, chemokine (C-C motif) ligand; CCR, chemokine (C-C motif) receptor; CX3CL, chemokine (C-X3-C motif) ligand; CXCL, chemokine (C-X-C motif) ligand; CXCR, chemokine (C-X-C motif) receptor; IP-10, IFN-γ-inducible protein 10; MCP, monocyte chemoattractant protein; MDC, macrophage-derived chemokine; MIP, macrophage inflammatory protein; MRP-1, MIP-related protein 1; NK, natural killer; PBS, phosphate-buffered saline; PF-4, platelet factor 4; p.i., postinfection; PMN, polymorphonuclear leukocyte; RANTES, regulated on activation, normal T-cell expressed and secreted; SDF-1, stromal cell-derived factor 1; TMEV, Theiler's murine encephalomyelitis virus.

  • b mRNA expression normalized to normal-brain control group.