TABLE 4.

EBV viral loada

AnimalEBVDPITumor presenceNo. of ApoB DNA copies/5 μlViral load (copies/5 μl)
1Mock51No133Undetected
2Mock56No30Undetected
3WT39Yes (type I)114Undetected
4WT51No31Undetected
5WT60Yes (type III)9825
6WT30No16Undetected
7WT32No51Undetected
8Z-KO57No70Undetected
9Z-KO24No4Undetected
10Z-KO3No258Undetected
11Z-KO60Yes (type III)25Undetected
12Z-KO51No68Undetected
13Z-KO32No8Undetected
  • a Q-PCR was performed (using primers to detect the BamHI repeat region of the EBV sequence) on purified plasma DNA collected from mock-infected, control virus-infected, or Z-KO EBV-infected animals at the time points indicated. The human ApoB gene DNA was quantitated in a separate well as a marker of the efficacy of extraction and amplification. The presence (or absence) of tumors in each animal is indicated. DPI indicates the day postinfection that plasma was collected.