TABLE 1

Correlations between virus shedding and cytokine, chemokine, or immune mediator gene expression for URT and LRT samples from ferrets infected with A(H1N1)pdm09 virus

Cytokine, chemokine, or immune mediatorCorrelation coefficient (P value)a
URTLRT
IL-1α0.2284 (0.0117)0.7886 (<0.0001)
IL-1β0.4221 (<0.0001)0.1569 (0.2118)
IL-60.6139 (<0.0001)0.7855 (<0.0001)
IL-12p400.2539 (0.001)0.4303 (0.0003)
TNF-α0.2898 (0.0001)0.3332 (0.00667)
IFN-α0.61 (<0.0001)0.6292 (<0.0001)
IFN-β0.9136 (<0.0001)0.6759 (<0.0001)
MCP1−0.06217 (0.4192)0.8161 (<0.0001)
IFN-γ−0.01088 (0.888)0.6291 (<0.0001)
Granzyme A−0.1866 (0.0413)−0.06643 (0.5990)
IL-10−0.1539 (0.0445)0.2984 (0.0157)
IL-17−0.09944 (0.2799)0.4319 (0.0003)
IL-8−0.09259 (0.2284)0.7886 (<0.0001)
IL-2Not detected0.1376 (0.2742)
  • a Pearson correlation coefficients were estimated for the relationship between virus shedding (fold change) and gene expression (fold change). P values shown in bold represent significant correlations.