TABLE 1

Conservatively defined HLA-associated HIV-1 polymerase polymorphismsa

Polymerase proteinHIV-1 polymorphismHLA alleleP value
Historic cohortModern cohort
ProteaseT12AB*52:010.0230.003
I15VB*51:010.0270.011
E35DB*44:021.12 × 10−56.40 × 10−6
I93LB*15:014.28 × 10−81.53 × 10−8
Reverse transcriptaseD123EB*35:011.12 × 10−62.95 × 10−4
I135TB*51:011.15 × 10−116.10 × 10−6
S162CB*07:020.020.011
D177EB*35:010.0080.007
K277RA*03:012.07 × 10−155.45 × 10−19
T468AB*13:020.0031.33 × 10−4
IntegraseE10DB*44:030.0010.04
E11DB*44:021.37 × 10−44.98 × 10−7
S24GB*51:012.49 × 10−50.008
V32IB*51:013.91 × 10−66.15 × 10−7
L45VB*51:010.0310.004
M50IC*16:010.0010.002
T122IB*57:010.0272.28 × 10−4
T122IC*05:012.58 × 10−84 × 10−4
T124NB*57:010.0026.24 × 10−4
G193EB*27:052.18 × 10−87.47 × 10−4
  • a Published polymorphisms identified via phylogenetically informed methods (8) detectable in both cohorts at a P value of <0.05 were included in the conservative definition.