TABLE 4

Comparison of relative activity for gp120 ELISA binding and ADCC and ADCP activities among hMAbs induced by DP6-001

VolunteerMAbFunctionActivitya for gp120 proteins from the following strains:
A2BBalCzmAE
ABL-034 (group A)HH1G9Binding++++++++++++++++++++
ADCC+++++++++++++
ADCP+++++++++++++++
HH2D11Binding++++++++++++++++++
ADCC++++++++++
ADCP++++++++++++
HH4E4Binding++++++++++++++++++++
ADCC++++++++++++
ADCP+++++++++++++++
ABL-001 (group B)GB1Binding+++++++++++++++++++
ADCC+++++++++++++++++
ADCP+++++++++
EA1Binding+++
ADCC+
ADCP++++
EA7Binding++++++++++++++
ADCC+++++++++++++
ADCP++++++++
EA8Binding++++++++++++++++++
ADCC++++++++++
ADCP+++++++++++
ABL003 (group B)CC3C2Binding++++
ADCC+
ADCP+++
CC6B5Binding+++++++++++
ADCC+++++++++++
ADCP+++++++++
CC6C11Binding+++++++++++++
ADCC+++++++++++++
ADCP+++++++++++
ABL040 (group C)TA6Binding+++++++++
ADCC+++
ADCP+++++++++++++
TA7Binding++++++
ADCC+++
ADCP+++++++++++
TB7Binding++++++++++
ADCC+
ADCP+++++++++
  • a −, dissociation complex 50 (DC50) for binding of >5 nM, <5% maximum GzB activity for ADCC, and maximum ADCP score of <5; +, DC50 for binding of 0.5 to 5 nM, 5% to 10% maximum GzB activity for ADCC, and maximum ADCP score of 5 to 10; ++, DC50 for binding of 0.05 to 0.5 nM, 10% to 15% maximum GzB activity for ADCC, and maximum ADCP score of 10 to 15; +++, DC50 for binding of 0.005 to 0.05 nM, 15% to 20% maximum GzB activity for ADCC, and maximum ADCP score of 15 to 20; ++++, DC50 for binding of <0.005 nM, >20% maximum GzB activity for ADCC, and maximum ADCP score of >20.