TABLE 3

Neutralization titers of hMAb TA6 by TZM-bl cell assaya

Study location, neutralization result, and virusCladeIC50 (μg/ml)
UMass
    Positive neutralization
        MNB27.5
        SF162B3.67
        SS1196B2.23
        QH0692.42B31.8
    Negative neutralization
        NL4-3B>50
        SC422661B>50
        WITO4160B>100
        ZM109F.PB4C>50
        Du156C>50
        Du422.1C>100
        ZM197.pB7C>50
        CM235.c11CRF01_AE>50
        816367.CO2CRF01_AE>50
        MLV>50
Harvard
    Positive neutralization
        SS1196.1B30.08
        T271-11CRF02_AG59.08
    Negative neutralization
        MS208.A1A>100
        Q23.17A>100
        MN-3B>100
        SF162.LSB>100
        BaL.26B>100
        6535.3B>100
        MW965.26C>100
        TV1.21C>100
        ZM109F.PB4C>100
        DJ263.8CRF02_AG>100
        242-14CRF02_AG>100
        TH023.6CRF01_AE>100
  • a IC50, 50% inhibitory concentration; UMass, University of Massachusetts Medical School; Harvard, Harvard Medical School; MLV, murine leukemia virus.