TABLE 1

Characteristics of hMAbs from volunteers in the DP6-001 trial

VolunteerhMAbWkEpitopeHeavy chainLight chain
Germ lineMutation %CDR3Germ line (chaina)Mutation %CDR3
ABL-034 (group A)HH1G936C2/C51-2*023162-28*01 (K)19
HH2D1136NDb1-2*023193-11*01 (K)08
HH4E436ND1-46*015187-43*01 (L)211
ABL-001 (group B)GB130C21-69*96181-5*03 (K)46
EA132C51-69*012193-10*01 (K)<111
EA732ND1-69*015143-19*01 (L)411
EA832ND4-39*019201-40*01 (L)311
ABL-003 (group B)CC3C236ND3-30*032231-44*01 (L)211
CC6B536C21-46*013121-26*01 (K)49
CC6C1136ND1-46*015121D-17*02 (K)19
ABL-040 (group C)TA630V31-3*015183-10*01 (L)311
TA730V31-3*014173-10*01 (L)111
TB730C2/C51-69*062232-14*01 (L)210
  • a K, kappa chain; L, lambda chain.

  • b ND, not determined.