TABLE 3

SIA binding pocket residue alignment (in VP1 numbering)a

AAV1AAV2AAV6AAV9
S268S268S268S269
D270D271D270D271
N271N272N271N272
Y445Y445Y445Y446
N447S446N447S448
G470G470G470N470
S472R471S472A472
V473D472V473V473
N500E499N500E500
T502S501T502A502
W503W502W503W503
SIAHSSIAGAL
  • a Residues in boldface indicate amino acids that play a role in binding the glycan indicated for each serotype. Underlined residues for AAV2 are the type to which structurally equivalent AAV1 and AAV6 residues were substituted to eliminate SIA binding.