TABLE 1

Summary of clinical and pathological findings

Inoculated virusMacaqueMHC genotypeaTime to death (weeks p.i.)Clinical and pathological findingsOpportunistic agent
SIVsmE543-3Rh824A08, B01105Seizures, interstitial pneumonia, splenomegaly, PMLSV40
Rh825A02, B01SurvivingN/AbN/A
Rh828A01, A08, B17SurvivingN/AN/A
Rh829NegativeSurvivingN/AN/A
Rh830A08SurvivingN/AN/A
Rh831B1795Lymphoproliferative disorder (kidney, lymph nodes, spleen), enteritisN/Dc
SIVsmE543-3 S37S98Rh826B0111Significant weight loss, diarrhea, severe enterocolitisBrachyspira
Rh827A02, A0863Severe diarrhea, severe enterocolitisCytomegalovirus
Rh832A01, B0193Diarrhea, lymphoproliferative disorder (kidney, lymph nodes, spleen), enteritisN/D
Rh833A08, B01, B0854Diarrhea, PML, esophagitis, enterocolitisCandida, SV40
Rh834B17SurvivingN/AN/A
Rh835Negative41Severe diarrhea, enterocolitis, focal pyogranulomatous lymphadenitisN/D
  • a Restrictive alleles Mamu-A01, -B08, and -B17 are shown in boldface.

  • b N/A, not available.

  • c N/D, not detected.