TABLE 4

Ranking C1C2-specific MAbs by ADCC breadth and potencya

TABLE 4
  • a RV305 and RV144 C1C2-specific MAbs were assayed for antibody-dependent cellular cytotoxicity against AE.CM235, B.WITO, C.TV-1, C.MW965, C.1086C, C.DU151, and C.DU422 infectious molecular clone-infected CEM.NKRCCR5 cells. MAbs were ranked using an ADCC score that accounts for breadth and potency (see Materials and Methods). Number of strains recognized was determined by ADCC endpoint concentration.