Odds ratios for the association between breast milk IgA binding to HIV-1 antigens by BAMA and HIV-1 transmission to the infant via breast milk in the BAN Study, Malawi

AntigenaLogistic regression model for transmitters
OR (95% CI)bP valuecFDRd
A1.con env03 gp1400.40 (0.17–0.93)0.0340.240
A244 gD- gp1200.82 (0.52–1.32)0.4190.488
B.con env03 gp1400.57 (0.38–0.86)0.0070.101
V3.C1.17 (0.72–1.88)0.5300.571
Bio-C1_104.BC0.76 (0.47–1.21)0.2420.408
4403 BMC5 gp1200.80 (0.53–1.21)0.2920.408
C10.67 (0.42–1.08)0.0980.314
Con6 gp120/B0.75 (0.52–1.09)0.1350.314
ConS gp1400.74 (0.51–1.09)0.1290.314
MN gp410.73 (0.50–1.06)0.0960.314
gp70 B.CaseA2_V1V2/169K1.24 (0.77–2.00)0.3810.485
gp70 B.CaseA_V1V21.32 (0.81–2.15)0.2690.408
gp70 C.1086C_V1V21.02 (0.64–1.64)0.9320.932
1086C gp1400.78 (0.55–1.11)0.1630.326
  • a Detailed descriptions of antigens can be found in Materials and Methods.

  • b Odds ratios (ORs) and 95% confidence intervals (CI) for binding antibody multiplex assay (BAMA) mean fluorescence intensities were determined by logistic regression modeling controlling for log10 plasma viral load and peripheral CD4+ T cell count. Significant odds ratios less than 1 indicate that nontransmitters have higher responses than transmitters.

  • c Immune variables with unadjusted P values of <0.05 are in boldface.

  • d FDR, false discovery rate.