TABLE 1

Clinical characteristics of transmitting and nontransmitting HIV-1-infected, non-antiretroviral therapy-treated maternal cohort from the Breastfeeding, Antiretrovirals, and Nutrition Study, Malawi

Parameter and groupaValue for the parameterP valuec
Median25th percentile75th percentile
Breast milk VL (log10 copies/ml)b
    Transmitters3.452.594.650.244
    Nontransmitters3.172.453.59
Plasma VL (log10 copies/ml)
    Transmitters4.844.295.140.003
    Nontransmitters4.203.804.60
No. of peripheral CD4+ T cells/μl
    Transmitters3242934450.950
    Nontransmitters327273446
Days postpartumd
    Transmitters48.528850.981
    Nontransmitters442984
Age (yr)
    Transmitters25.522310.582
    Nontransmitters252228
Gravida
    Transmitters3240.779
    Nontransmitters324
  • a The data represent 22 transmitting and 65 nontransmitting mothers except for breast milk VL as noted. VL, viral load.

  • b No target was detected in breast milk samples from 3 transmitters and 30 nontransmitters, and three additional breast milk samples from nontransmitters were below the level of quantitation (100 copies/ml).

  • c Wilcoxon test. A significant difference (P < 0.05) in plasma viral loads between transmitters and nontransmitters is indicated in boldface.

  • d The time point represents the last visit prior to infant HIV-1 diagnosis for the transmitting women; samples from nontransmitting women were matched by days postpartum and CD4+ T cell count.