TABLE 2

WT and mutant HIV-1 susceptibility to NNRTIs

VirusEC50a (fold change above WT)
Compound 13RPVEFVETRNVP
WT1 ± 0.2 (1)0.4 ± 0.1 (1)11 ± 1 (1)0.7 ± 0.08 (1)79 ± 18 (1)
G112D1 ± 0.3 (1)0.7 ± 0.04 (2)13 ± 2 (1)0.8 ± 0.1 (1)52 ± 11 (1)
M230I9 ± 1 (7)4 ± 0.6 (10)89 ± 9 (8)5 ± 0.2 (7)838 ± 262 (11)
G112D/M230I25 ± 2 (20)12 ± 1 (30)194 ± 40 (18)11 ± 0.9 (17)1,341 ± 163 (17)
  • a Nanomolar concentration, shown as average (standard deviation) of 3 or 4 independent experiments, each performed in triplicate. Bold indicates that the P value was <0.05 compared to the WT value in all independent experiments.