TABLE 1

Mutations in the BG505 immunogen trimersa

GroupTrimeraAdded mutation(s)
1SOSIP.v4.1 (parental)
2SOSIP.v4.1 + N241-KIS241N
3SOSIP.v4.1 + N241-KI + N130-KIS241N + Q130N
4SOSIP.v4.1 + N241-KI + N197-KOS241N + N197D
5SOSIP.v4.1 + N241-KI + N234-KOS241N + N234S
6SOSIP.v4.1 + N241-KI + N276-KOS241N + T278A
7SOSIP.v4.1 + N241-KI + N332-KOS241N + N332T
8SOSIP.v4.1 + N241-KI + N355-KOS241N + N355D + N356K
  • a All trimers were based on the BG505.T332N parental genotype. They contained the standard SOS and I559P amino acid substitutions of the SOSIP.664 trimer design (15) plus the E64K and A316W changes that create the further-stabilized SOSIP.v4.1 version (27).