TABLE 2

Functional enrichment analysis of CVS proteome in live HSV-2-inoculated RM

Function type and termCountP valueBonferroniGenes
Functions associated with proteins differentially expressed on day 1 relative to baseline (day 0)
    Response to wounding311.51E−136.97E−11A2M, C3, C6, C5, PRDX2, PF4, AHSG, FGG, FGA, FGB, FCN2, RAC1, SERPINC1, CFH, KRT1, APOH, VNN1, SERPINA1, THBS1, KLK6, APCS, C4A, SAA4, C4BPA, ANXA5, SERPINB2, DSP, LTA4H, SERPIND1, IL1F6, PROS1
    Defense response243.50E−071.62E−04A2M, APCS, C4A, C3, S100A7, C6, C5, SAA4, PRDX2, CD5L, HP, C4BPA, COTL1, AHSG, FCN2, RAC1, KRT1, CFH, LTF, VNN1, LTA4H, SERPINA1, THBS1, IL1F6
    Regulation of immune system process181.48E−066.84E−04A2M, C4A, C3, IL6ST, C6, C5, PF4, PRDX2, C4BPA, AMBP, APOA1, HPX, FCN2, CFH, KRT1, VNN1, CA2, THBS1
    Blood coagulation102.09E−069.65E−04FGG, FGA, FGB, APOH, SERPINC1, PF4, SERPINA1, SERPIND1, ANXA5, PROS1
    Humoral immune response92.77E−061.28E−03C4A, C3, FCN2, C6, C5, CFH, KRT1, LTF, C4BPA
    Regulation of immune response138.99E−064.16E−03AMBP, A2M, APOA1, C4A, HPX, IL6ST, C3, FCN2, C6, C5, KRT1, CFH, C4BPA
Carbohydrate catabolic process93.04E−051.40E−02GNS, TPI1, GM2A, PGD, PGAM1, BPGM, GAPDH, MDH1, ENO1
Functions associated with proteins differentially expressed on day 2 relative to baseline (day 0)
    Inflammatory response171.12E−087.48E−06TF, A2M, APCS, C4A, C3, C6, C5, SAA4, PRDX2, C1S, AHSG, FCN2, KRT1, CFH, VNN1, SERPINA1, THBS1
    Carbohydrate catabolic process103.01E−072.02E−04TPI1, GM2A, NUDT5, PGD, MGAM, PGAM1, BPGM, GAPDH, MDH1, ENO1
    Blood coagulation92.09E−061.40E−03FGG, FGA, FGB, APOH, SERPINC1, SERPINA1, SERPIND1, ANXA5, PROS1
    Regulation of immune response122.85E−061.91E−03AMBP, A2M, APOA1, C4A, C3, HPX, FCN2, C6, C5, CFH, KRT1, C1S
    Epidermis development116.24E−064.17E−03KRT6A, KRT17, KRT5, KRT16, KRT15, KRT1, ALOX12B, DSP, KRT13, KRT2, KRT10
    Response to metal ion91.21E−058.05E−03ACTB, FGG, APOB, FGA, FGB, ANXA11, SERPINA1, CA2, THBS1
    Wound healing103.09E−052.05E−02FGG, FGA, FGB, APOH, SERPINC1, DSP, SERPINA1, SERPIND1, ANXA5, PROS1
Functions associated with proteins differentially expressed on day 29 relative to baseline (day 0)
    Response to wounding256.32E−122.60E−09TF, A2M, C3, C5, PF4, PRDX2, C1S, AHSG, FGG, FGA, FGB, KRT1, SERPINC1, VNN1, SERPINA1, THBS1, APCS, C4A, C4BPA, ANXA5, VWF, DSP, SERPIND1, IL1F6, PROS1
    Blood coagulation101.53E−076.30E−05VWF, FGG, FGA, FGB, SERPINC1, PF4, SERPINA1, SERPIND1, ANXA5, PROS1
    Defense response192.62E−061.07E−03TF, A2M, APCS, C4A, C3, S100A7, C5, CD5L, HP, PRDX2, C4BPA, C1S, COTL1, AHSG, KRT1, VNN1, SERPINA1, THBS1, IL1F6
    Regulation of immune system process141.66E−056.80E−03A2M, APOA1, C4A, HPX, C3, C5, KRT1, VNN1, PRDX2, PF4, CA2, C1S, C4BPA, THBS1
    Complement activation62.32E−059.50E−03C4A, C3, C5, KRT1, C1S, C4BPA
    Tissue development171.07E−044.30E−02MYL6, KRT6A, S100A7, KRT13, KRT10, SCEL, FGA, KRT16, KRT15, AGT, KRT1, ALOX12B, DSP, KRT2, KRT3, KRT4, CA2