TABLE 1

Modulation of antiviral gene expression by ZIKV infection

GeneFold change in gene expression at indicated time postinfectiona
6 h24 h
AIM25.7719.67
APOBEC3G3.312.64
ATG5−1.141.06
AZI21.241.96
CARD8−1.71−1.36
CASP12.822.67
CASP103.273.31
CASP81.961.31
CCL3−1.71−1.36
CCL51.525.65
CD401.90−1.14
CD80−1.71−1.36
CD86−1.71152.01
CHUK1.01−1.16
CTSB1.11−1.00
CTSL1−1.00−1.11
CTSS2.482.07
CXCL10−47.9012.54
CXCL11−6.242.05
CXCL9−5.55−1.36
CYLD−1.92−1.55
DAK2.002.28
DDX3X1.27−1.06
DDX58−3.164.88
DHX581.762.64
FADD−1.34−1.08
FOS−1.932.29
HSP90AA11.421.44
IFIH1−1.377.30
IFNA12.343.36
IFNA2−1.71−1.36
IFNAR1−1.35−1.30
IFNB1−1.713.70
IKBKB1.671.06
IL-12A1.53−1.10
IL-12B−1.73−1.36
IL-15−1.041.27
IL-18−1.63−1.74
IL1B−3.21−5.29
IL-61.138.21
IL-8−2.833.73
IRAK11.401.61
IRF3−1.14−1.08
IRF5−2.031.26
IRF71.253.16
ISG15−1.108.33
JUN5.732.53
MAP2K1−1.02−1.12
MAP2K3−1.021.01
MAP3K12.34−1.48
MAP3K7−1.15−1.29
MAPK11.261.01
MAPK141.37−1.22
MAPK31.421.25
MAPK8−1.21−1.26
MAVS−1.02−1.53
MEFV−648.972.62
MX11.0827.44
MYD88−1.031.76
NFKB11.221.63
NFKBIA−3.321.55
NLRP3−1.711.12
NOD2−1.71−1.36
OAS21.1416.66
PIN11.621.09
PSTPIP1−1.191.05
PYCARD1.791.80
PYDC1−1.36−1.36
RELA1.16−1.05
RIPK11.621.40
SPP1−1.88−1.27
STAT11.071.75
SUGT11.28−1.00
TBK1−1.201.07
TICAM11.491.52
TLR32.082.73
TLR7−1.71−1.36
TLR8−1.71−1.36
TLR9−1.00−2.25
TNF−1.71−2.13
TRADD1.501.26
TRAF3−1.591.35
TRAF61.32−1.13
TRIM251.431.83
  • a Values represent fold inductions of mRNA copy numbers in infected cells relative to mock-infected cells. Values in bold indicate differentially expressed genes.