TABLE 2.

Summary of mutant phenotypes

Group no.Location(s) of CA changesRelative infectivity in monkey cells compared to wtRelative ability to compete for restricting factors in monkey cells compared to wtEffect of CspA on infectivity in HeLa cells
1CypA-binding loop and Ser149 (phosphorylation site)IncreaseDecreaseIncrease or no change
2Helix 3/6 ridgeIncreaseIncreaseDecrease