TABLE 1.

Transmission of CWD prions to Tg(CerPrP) mice

InoculumSpeciesRecipientMean ± SE incubation time in daysa
CWD poolMule deerTg(CerPrP)1536+/−264 ± 3 (7/7)
Db99Mule deerTg(CerPrP)1536+/−259 ± 4 (7/7)
D10Mule deerTg(CerPrP)1536+/−225 ± 1 (8/8)
7378ElkTg(CerPrP)1536+/−235 ± 2 (8/8)
RMLMouse-adapted scrapieTg(CerPrP)1536+/−>385 (0/8)
PBSTg(CerPrP)1536+/−>360 (0/8)
D10Mule deerTg(CerPrP)1536+/+160 ± 3 (7/7)
CWD poolMule deerTg(CerPrP)1534+/−268 ± 2 (10/10)
PBSTg(CerPrP)1534+/−>300 (0/6)
CWD poolMule deerWild-type mice>596 (0/7)
  • a The number of mice developing clinical signs of prion disease divided by the original number of inoculated mice is shown in parentheses.