TABLE 1.

DENV cross-neutralizing activities of Fabs identified by panning against DENV-1, DENV-2, or DENV-3

FabaPanning antigenPRNT50 titer (μg/ml) against:
DENV-1DENV-2DENV-3DENV-4
2H7DENV-10.260.335.927.26
2H5DENV-10.470.5320.89.26
1A5DENV-20.490.773.494.23
1A10DENV-20.945.2626.312.6
1B2DENV-20.503.13>10029.2
3A2DENV-30.371.332.994.71
3E4DENV-442.7>100>10040.5
  • a Fabs which are underlined shared a similar VH sequence or VL sequence. Fab 3E4 was recovered from a chimpanzee after primary infection by panning against DENV-4, as described previously (26). Fab 3E4 was included for comparison with Fab 1A10.