TABLE 2.

Packaging efficiencies of KUN replicon RNAs with different cell-adaptive mutations

MutationPackaging efficiency (PFu/ml) on day:
2468
Wt5 × 1061.3 × 1081.8 × 1083.3 × 108
NS2A/A30P4 × 1061 × 1083.4 × 1086 × 108
NS2A/N101D4.4 × 1041.3 × 1074 × 107NDa
NS5/P270S1.0 × 1056 × 1071.3 × 108ND
NS2A/A30P/N101D1 × 1041.1 × 1051.2 × 1069 × 106
  • a ND, not determined.